S
IPR020611

Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site

InterPro entry
Short nameCu2_ascorb_mOase_CS-1

Description

Copper type II, ascorbate-dependent monooxygenases
[1]
are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase (
1.14.17.1
) and peptidyl-glycine alpha-amidating monooxygenase (
1.14.17.3
). There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.

This entry represents a conserved site that covers the first cluster of conserved histidine residues.

References

1.Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain. Southan C, Kruse LI. FEBS Lett. 255, 116-20, (1989). View articlePMID: 2792366

GO terms

Cross References

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