IPR020611
Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
InterPro entry
Short name | Cu2_ascorb_mOase_CS-1 |
Description
Copper type II, ascorbate-dependent monooxygenases
[1] are a class of enzymes that requires copper as a cofactor and which uses ascorbate as an electron donor. This family contains two related enzymes, dopamine-beta-monooxygenase (
1.14.17.1) and peptidyl-glycine alpha-amidating monooxygenase (
1.14.17.3). There are a few regions of sequence similarities between these two enzymes, two of these regions contain clusters of conserved histidine residues which are most probably involved in binding copper.
This entry represents a conserved site that covers the first cluster of conserved histidine residues.
References
1.Sequence similarity between dopamine beta-hydroxylase and peptide alpha-amidating enzyme: evidence for a conserved catalytic domain. Southan C, Kruse LI. FEBS Lett. 255, 116-20, (1989). View articlePMID: 2792366
GO terms
biological process
- None
cellular component
- None
Cross References
Contributing Member Database Entry
- PROSITE patterns:PS00084