F
IPR020946

Flavin monooxygenase-like

InterPro entry
Short nameFlavin_mOase-like
Overlapping
homologous
superfamilies
 
family relationships

Description

Flavin-containing monooxygenases (FMOs) constitute a family of xenobiotic-metabolising enzymes
[1]
. Using an NADPH cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorus and selenium atoms in a range of structurally diverse compounds. FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants. In man, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome). Five mammalian forms of FMO are now known and have been designated FMO1-FMO5
[6, 5, 2, 3, 7, 9]
. This is a recent nomenclature based on comparison of amino acid sequences, and has been introduced in an attempt to eliminate confusion inherent in multiple, laboratory-specific designations and tissue-based classifications
[1]
. Following the determination of the complete nucleotide sequence of Saccharomyces cerevisiae (Baker's yeast)
[4]
, a novel gene was found to encode a protein with similarity to mammalian monooxygenases. In Aspergillus, flavin-containing monooxygenases ustF1 and ustF2 are components in the biosynthesis of the antimitotic tetrapeptide ustiloxin B, a secondary metabolite. The monooxygenases modify the side chain of the intermediate S-deoxyustiloxin H
[8]
.

References

1.A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. Lawton MP, Cashman JR, Cresteil T, Dolphin CT, Elfarra AA, Hines RN, Hodgson E, Kimura T, Ozols J, Phillips IR. Arch. Biochem. Biophys. 308, 254-7, (1994). View articlePMID: 8311461

2.Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver. Lomri N, Gu Q, Cashman JR. Proc. Natl. Acad. Sci. U.S.A. 89, 1685-9, (1992). View articlePMID: 1542660

3.Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. Dolphin CT, Shephard EA, Povey S, Smith RL, Phillips IR. Biochem. J. 287 ( Pt 1), 261-7, (1992). View articlePMID: 1417778

4.Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, Andrews S, Brinkman R, Cooper J, Ding H, Dover J, Du Z, Favello A, Fulton L, Gattung S. Science 265, 2077-82, (1994). View articlePMID: 8091229

5.The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes. Lawton MP, Gasser R, Tynes RE, Hodgson E, Philpot RM. J. Biol. Chem. 265, 5855-61, (1990). View articlePMID: 2318837

6.Cloning, primary sequence, and chromosomal mapping of a human flavin-containing monooxygenase (FMO1). Dolphin C, Shephard EA, Povey S, Palmer CN, Ziegler DM, Ayesh R, Smith RL, Phillips IR. J. Biol. Chem. 266, 12379-85, (1991). View articlePMID: 1712018

7.Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase 1C1. Evidence for a third gene subfamily in rabbits. Atta-Asafo-Adjei E, Lawton MP, Philpot RM. J. Biol. Chem. 268, 9681-9, (1993). View articlePMID: 8486656

8.Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi. Ye Y, Minami A, Igarashi Y, Izumikawa M, Umemura M, Nagano N, Machida M, Kawahara T, Shin-Ya K, Gomi K, Oikawa H. Angew. Chem. Int. Ed. Engl. 55, 8072-5, (2016). View articlePMID: 27166860

9.Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. Veeravalli S, Phillips IR, Freire RT, Varshavi D, Everett JR, Shephard EA. Drug Metab Dispos 48, 378-385, (2020). PMID: 32156684

GO terms

Cross References

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