D
IPR021027

Transposase, putative, helix-turn-helix domain

InterPro entry
Short nameTransposase_put_HTH

Description

This entry represents an N-terminal helix-turn-helix domain found in a variety of putative transposases
[1, 2, 3]
, such as A625R from Paramecium bursaria Chlorella virus 1 and in RNA-guided DNA endonucleases, including TnpB from Deinococcus radiodurans, an RNA-guided dsDNA endonuclease that cleaves DNA downstream of the 5'-TTGAT-3' transposon-associated motif (TAM) guided by RNA derived from the right-end element of its insertion sequence element
[4]
. This domain is usually associated with
IPR001959
and
IPR010095
.

References

1.Characterization of an insertion sequence (IS891) of novel structure from the cyanobacterium Anabaena sp. strain M-131. Bancroft I, Wolk CP. J. Bacteriol. 171, 5949-54, (1989). View articlePMID: 2553665

2.IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea. Donadio S, Staver MJ. Gene 126, 147-51, (1993). View articlePMID: 8386127

3.A novel insertion sequence (IS)-like element of the thermophilic bacterium PS3 promotes expression of the alanine carrier protein-encoding gene. Murai N, Kamata H, Nagashima Y, Yagisawa H, Hirata H. Gene 163, 103-7, (1995). View articlePMID: 7557457

4.Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease. Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, Kazlauskas D, Venclovas C, Siksnys V. Nature 599, 692-696, (2021). PMID: 34619744

Cross References

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