F
IPR021045

Influenza A proapoptotic protein PB1-F2

InterPro entry
Short nameFlu_proapoptotic_PB1-F2

Description

PB1-F2 is a protein found in almost all known strains of Influenza A virus - a negative sense ssRNA Orthomyxovirus
[1]
. It originates from translation of the viral polymerase gene in an alternative reading frame
[1]
. PB1-F2 consists of two independent structural domains, two closely neighbouring short helices at the N terminus, and an extended C-terminal helix
[1]
. Although the protein has originally been described to induce apoptosis, it has now been shown that PB1-F2 more likely acts as an apoptosis promoter in concert with other apoptosis-inducing agents
[1]
. PB1-F2 promotes apoptosis by localising to the mitochondria where it destabilises the membrane. This will cause release of cytochrome C which activates the caspase cascade of apoptosis through the endogenous pathway
[1]
. In this way it acts like the Bcl-2 protein family which are physiological apoptotic regulators in cells
[1]
.

References

1.Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein. Bruns K, Studtrucker N, Sharma A, Fossen T, Mitzner D, Eissmann A, Tessmer U, Roder R, Henklein P, Wray V, Schubert U. J. Biol. Chem. 282, 353-63, (2007). View articlePMID: 17052982

Cross References

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