D
IPR021051

Herpes simplex virus, Tegument protein VP16, C-terminal

InterPro entry
Short nameHSV_VP16_C

Description

This domain is found in the C-terminal region of the HSV virion protein 16 (VP16 or Alpha-TIF) from Herpes Simplex virus. It appears in association with
PF02232
and is about 30 amino acids in length. It is the carboxyl subdomain of the acidic transcriptional activation domain.

VP16 is a transcription promoter, an essential activator of viral immediate early (IE) promoters (alpha genes) during the lytic phase of viral infection. The protein associates with cellular transcription factors and DNA binding proteins to to enhance transcription rates. Such proteins include TATA binding protein, CBP, TBP-binding protein, etc. The C-terminal residues of the protein are responsible for transcriptional activation. Within the C-terminal region there are two activation regions that can independently and cooperatively activate transcription
[1, 3, 2]
.

References

1.Structural properties of the promiscuous VP16 activation domain. Jonker HR, Wechselberger RW, Boelens R, Folkers GE, Kaptein R. Biochemistry 44, 827-39, (2005). View articlePMID: 15654739

2.The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Wysocka J, Herr W. Trends Biochem. Sci. 28, 294-304, (2003). View articlePMID: 12826401

3.NMR structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of VP16: structural similarities between VP16 and p53. Langlois C, Mas C, Di Lello P, Jenkins LM, Legault P, Omichinski JG. J. Am. Chem. Soc. 130, 10596-604, (2008). View articlePMID: 18630911

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