D
IPR023302

Peptidase S9A, N-terminal domain

InterPro entry
Short namePept_S9A_N
Overlapping
homologous
superfamilies
 

Description

This entry represents the β-propeller domain found at the N-terminal of prolyl oligopeptidase from the MEROPS peptidase family S9A. The prolyl oligopeptidase family consist of a number of evolutionary related peptidases whose catalytic activity seems to be provided by a charge relay system similar to that of the trypsin family of serine proteases, but which evolved by independent convergent evolution. The N-terminal domain of prolyl oligopeptidases form an unusual 7-bladed β-propeller consisting of seven 4-stranded β-sheet motifs.

Prolyl oligopeptidase is a large cytosolic enzyme involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The enzyme contains a peptidase domain, where its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of the N-terminal β-propeller domain. In this way, large structured peptides are excluded from the active site, thereby protecting larger peptides and proteins from proteolysis in the cytosol
[1]
.

References

1.Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. Fulop V, Bocskei Z, Polgar L. Cell 94, 161-70, (1998). View articlePMID: 9695945

GO terms

biological process

  • None

cellular component

  • None

Cross References

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