H
IPR023343

Penicillin amidase type, domain 1

InterPro entry
Short namePenicillin_amidase_dom1
Overlapping entries
 

Description

Penicillin amidase or penicillin acylase catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins
[2]
.

This superfamily represents the N-terminal structural domain of the penicillin amidase peptidases. It forms an α-helical orthogonal bundle
[1]
. This domain is also found in other S45 peptidases like Glutaryl-7-aminocephalosporanic-acid acylase.

References

1.Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism. McVey CE, Walsh MA, Dodson GG, Wilson KS, Brannigan JA. J. Mol. Biol. 313, 139-50, (2001). View articlePMID: 11601852

2.Molecular cloning and analysis of the gene encoding the thermostable penicillin G acylase from Alcaligenes faecalis. Verhaert RM, Riemens AM, van der Laan JM, van Duin J, Quax WJ. Appl. Environ. Microbiol. 63, 3412-8, (1997). View articlePMID: 9292993

GO terms

Cross References

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