IPR023343
Penicillin amidase type, domain 1
InterPro entry
Short name | Penicillin_amidase_dom1 |
Overlapping entries |
Description
Penicillin amidase or penicillin acylase catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins
[2].
This superfamily represents the N-terminal structural domain of the penicillin amidase peptidases. It forms an α-helical orthogonal bundle
[1]. This domain is also found in other S45 peptidases like Glutaryl-7-aminocephalosporanic-acid acylase.
References
1.Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism. McVey CE, Walsh MA, Dodson GG, Wilson KS, Brannigan JA. J. Mol. Biol. 313, 139-50, (2001). View articlePMID: 11601852
2.Molecular cloning and analysis of the gene encoding the thermostable penicillin G acylase from Alcaligenes faecalis. Verhaert RM, Riemens AM, van der Laan JM, van Duin J, Quax WJ. Appl. Environ. Microbiol. 63, 3412-8, (1997). View articlePMID: 9292993
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:1.10.439.10
Representative structure
4yfb: Structure of N-acylhomoserine lactone acylase MacQ in complex with phenylacetic acid