F
IPR023426

Flap endonuclease 1

InterPro entry
Short nameFlap_endonuc
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents an endonuclease that cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment
[1]
. It has 5'-endo-/exonuclease and 5'-pseudo-Y-endonuclease activities and cleaves the junction between single and double-stranded regions of flap DNA.

References

1.Characterization of FEN-1 from Xenopus laevis. cDNA cloning and role in DNA metabolism. Bibikova M, Wu B, Chi E, Kim KH, Trautman JK, Carroll D. J. Biol. Chem. 273, 34222-9, (1998). View articlePMID: 9852084

GO terms

biological process

  • None

cellular component

  • None
Contributing Member Database Entry
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