F
IPR023464

DNA-directed RNA polymerase subunit Rpo12

InterPro entry
Short nameRpo12
Overlapping
homologous
superfamilies
 
family relationships

Description

DNA-directed RNA polymerases, also known as DNA-dependent RNA polymerases, are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. Eukaryotes have three different DNA-directed RNA polymerases (RNAPs), Pol I, II, and III, whereas Archaea and Bacteria have single enzymes.

RNAPs are multisubunit enzymes. Archaeal RNAP is closely related to eukaryotic RNAP II
[1]
, which consists of 12 subunits. Archaeal RNAP has an additional subunit, Rpo13, with no orthologue in the eukaryotic enzyme
[2]
.

This entry represents the archaeal RNA polymerase subunit P, also known as Rpo12 following the eukaryotic nomenclature
[2]
. Archaeal subunit P is the homologue of eukaryotic subunit Rbp12
[3]
.

References

1.Archaeal RNA polymerase. Hirata A, Murakami KS. Curr. Opin. Struct. Biol. 19, 724-31, (2009). View articlePMID: 19880312

2.Evolution of Complex RNA Polymerases: The Complete Archaeal RNA Polymerase Structure. Korkhin Y, Unligil UM, Littlefield O, Nelson PJ, Stuart DI, Sigler PB, Bell SD, Abrescia NG. PLoS Biol. 7, e102, (2009). View articlePMID: 19419240

3.Archaeal RNA polymerase subunits F and P are bona fide homologs of eukaryotic RPB4 and RPB12. Werner F, Eloranta JJ, Weinzierl RO. Nucleic Acids Res. 28, 4299-305, (2000). View articlePMID: 11058130

GO terms

Cross References

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