F
IPR023940

Dihydrodipicolinate reductase

InterPro entry
Short nameDHDPR_bac
Overlapping
homologous
superfamilies
 
family relationships

Description

Dihydrodipicolinate reductase (DHDPR), a product of an essential gene referred to as dapB, catalyzes the second step of lysine biosynthesis
[4, 2]
. It catalyses the reduction of 2,3-dihydrodipicolinate (DHDP) to 2,3,4,5-tetrahydrodipicolinate (THDP) in a nucleotide dependent reaction
[1]
:

2,3-dihydrodipicolinate + NAD(P)H = 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+)

Interestingly, DHDPR could also function as a dehydratase in addition to the role of a nucleotide dependent reductase
[3]
.

References

1.Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy. Blickling S, Renner C, Laber B, Pohlenz HD, Holak TA, Huber R. Biochemistry 36, 24-33, (1997). View articlePMID: 8993314

2.Cloning, expression, crystallization and preliminary structural studies of dihydrodipicolinate reductase from Acinetobacter baumannii. Kaushik S, Singh A, Sinha M, Kaur P, Sharma S, Singh TP. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69, 653-6, (2013). View articlePMID: 23722845

3.NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase. Devenish SR, Blunt JW, Gerrard JA. J. Med. Chem. 53, 4808-12, (2010). View articlePMID: 20503968

4.Structure and nucleotide specificity of Staphylococcus aureus dihydrodipicolinate reductase (DapB). Girish TS, Navratna V, Gopal B. FEBS Lett. 585, 2561-7, (2011). View articlePMID: 21803042

Further reading

5. The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity. Cirilli M, Zheng R, Scapin G, Blanchard JS. Biochemistry 42, 10644-50, (2003). View articlePMID: 12962488

6. Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase. Scapin G, Blanchard JS, Sacchettini JC. Biochemistry 34, 3502-12, (1995). View articlePMID: 7893645

GO terms

Cross References

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