IPR024668
GA-binding protein alpha subunit, N-terminal
InterPro entry
Short name | GABP_asu_N |
Description
GA-binding protein alpha is a transcription factor capable of interacting with purine rich repeats (GA repeats). This N-terminal domain found in the transcription factor GABP alpha consists of a five-stranded β-sheet crossed by a distorted helix and has been termed OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300
[1].
References
1.Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. Kang HS, Nelson ML, Mackereth CD, Scharpf M, Graves BJ, McIntosh LP. J. Mol. Biol. 377, 636-46, (2008). View articlePMID: 18295234
Contributing Member Database Entry
- Pfam:PF11620