D
IPR024668

GA-binding protein alpha subunit, N-terminal

InterPro entry
Short nameGABP_asu_N

Description

GA-binding protein alpha is a transcription factor capable of interacting with purine rich repeats (GA repeats). This N-terminal domain found in the transcription factor GABP alpha consists of a five-stranded β-sheet crossed by a distorted helix and has been termed OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300
[1]
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References

1.Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. Kang HS, Nelson ML, Mackereth CD, Scharpf M, Graves BJ, McIntosh LP. J. Mol. Biol. 377, 636-46, (2008). View articlePMID: 18295234

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