D
IPR024964

CTLH/CRA C-terminal to LisH motif domain

InterPro entry
Short nameCTLH/CRA

Description

RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. The RanBPM protein contains multiple conserved domains that provide potential protein-protein interaction sites
[3]
. This entry represents a domain at the C terminus of RanBPM containing the CT11-RanBPM (CRA) motif. The CRA motif was found to be important for the interaction of RanBPM with fragile X messenger ribonucleoprotein 1 (FMRP), but its functional significance has yet to be determined
[1]
. The region comprising this domain contains the CTLH and CRA domains annotated by SMART; however, these may be a single domain, and is referred to as a C-terminal to LisH motif
[2]
.

References

1.The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. Menon RP, Gibson TJ, Pastore A. J. Mol. Biol. 343, 43-53, (2004). View articlePMID: 15381419

2.A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration. Emes RD, Ponting CP. Hum. Mol. Genet. 10, 2813-20, (2001). View articlePMID: 11734546

3.Diverse roles of the scaffolding protein RanBPM. Suresh B, Ramakrishna S, Baek KH. Drug Discov. Today (2011). PMID: 22094242

Cross References

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