IPR025745
Restriction system protein Mrr-like N-terminal domain
InterPro entry
Short name | Mrr-like_N_dom |
Description
This domain is found N-terminal to the catalytic domain in Mrr restriction endonucleases
[1, 2]. It is also found in other proteins, including predicted methyltransferases and ATPases. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition
[2].
References
1.Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs. Bujnicki JM, Rychlewski L. Gene 267, 183-91, (2001). View articlePMID: 11313145
2.Mutational analysis and a structural model of methyl-directed restriction enzyme Mrr. Orlowski J, Mebrhatu MT, Michiels CW, Bujnicki JM, Aertsen A. Biochem. Biophys. Res. Commun. 377, 862-6, (2008). View articlePMID: 18951880
Contributing Member Database Entry
- Pfam:PF14338