D
IPR025745

Restriction system protein Mrr-like N-terminal domain

InterPro entry
Short nameMrr-like_N_dom

Description

This domain is found N-terminal to the catalytic domain in Mrr restriction endonucleases
[1, 2]
. It is also found in other proteins, including predicted methyltransferases and ATPases. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition
[2]
.

References

1.Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs. Bujnicki JM, Rychlewski L. Gene 267, 183-91, (2001). View articlePMID: 11313145

2.Mutational analysis and a structural model of methyl-directed restriction enzyme Mrr. Orlowski J, Mebrhatu MT, Michiels CW, Bujnicki JM, Aertsen A. Biochem. Biophys. Res. Commun. 377, 862-6, (2008). View articlePMID: 18951880

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