D
IPR025871

Growth hormone-binding protein

InterPro entry
Short nameGHBP

Description

Growth hormone receptor binding protein is produced either by proteolysis of the growth hormone receptor (GHR) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme)
[1, 4]
.

Growth hormone (GH) binding to GH receptor is the initial step that leads to the physiological functions of the hormone
[2]
. The biological effects of GHBP are determined by the serum levels of GH, which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage
[3]
.

References

1.Growth hormone receptor and serum binding protein: purification, cloning and expression. Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI. Nature 330, 537-43, (1987). View articlePMID: 2825030

2.Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver. Gonzalez L, Curto LM, Miquet JG, Bartke A, Turyn D, Sotelo AI. Growth Horm. IGF Res. 17, 104-12, (2007). View articlePMID: 17321774

3.Biological effects of growth hormone and its antagonist. Okada S, Kopchick JJ. Trends Mol Med 7, 126-32, (2001). View articlePMID: 11286784

4.The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE). Schantl JA, Roza M, Van Kerkhof P, Strous GJ. Biochem. J. 377, 379-84, (2004). View articlePMID: 14519102

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