F
IPR026164

Integrator complex subunit 10

InterPro entry
Short nameInt_cplx_su10

Description

Integrator complex subunit 10 is a component of the multiprotein complex Integrator, which is responsible for the endonucleolytic cleavage of small nuclear RNA (snRNA) transcripts within the nucleus
[2, 1]
.

The Integrator is an RNA polymerase II complex which contains at least 12 novel subunits and core RNAPII subunits. Two of the Integrator subunits share similarity with subunits of the cleavage and polyadenylation specificity factor (CPSF) complex. Integrator has been shown to be recruited to the U1 and U2 snRNA genes, and to mediate the snRNAs' 3' end processing. The Integrator complex is evolutionarily conserved in metazoans, and directly interacts with the C-terminal domain of the RNA polymerase II largest subunit
[3]
.

References

1.The integrator complex is required for integrity of Cajal bodies. Takata H, Nishijima H, Maeshima K, Shibahara K. J. Cell. Sci. 125, 166-75, (2012). View articlePMID: 22250197

2.snRNA 3' end formation requires heterodimeric association of integrator subunits. Albrecht TR, Wagner EJ. Mol. Cell. Biol. 32, 1112-23, (2012). View articlePMID: 22252320

3.Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R. Cell 123, 265-76, (2005). View articlePMID: 16239144

GO terms

molecular function

  • None
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