IPR026164
Integrator complex subunit 10
InterPro entry
Short name | Int_cplx_su10 |
Description
The Integrator is an RNA polymerase II complex which contains at least 12 novel subunits and core RNAPII subunits. Two of the Integrator subunits share similarity with subunits of the cleavage and polyadenylation specificity factor (CPSF) complex. Integrator has been shown to be recruited to the U1 and U2 snRNA genes, and to mediate the snRNAs' 3' end processing. The Integrator complex is evolutionarily conserved in metazoans, and directly interacts with the C-terminal domain of the RNA polymerase II largest subunit
[3].
References
1.The integrator complex is required for integrity of Cajal bodies. Takata H, Nishijima H, Maeshima K, Shibahara K. J. Cell. Sci. 125, 166-75, (2012). View articlePMID: 22250197
2.snRNA 3' end formation requires heterodimeric association of integrator subunits. Albrecht TR, Wagner EJ. Mol. Cell. Biol. 32, 1112-23, (2012). View articlePMID: 22252320
3.Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R. Cell 123, 265-76, (2005). View articlePMID: 16239144
GO terms
biological process
molecular function
- None
cellular component