F
IPR026283

Beta-galactosidase 1-like

InterPro entry
Short nameB-gal_1-like
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents a subset of the glycosyl hydrolase 35 family, including beta-galactosidase (B-gal), B-gal-1, B-gal-1-like, B-gal-8, B-gal-17. Mammalian beta-galactosidase is a lysosomal enzyme (gene GLB1) which cleaves the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans and whose deficiency is the cause of the genetic disease Gm(1) gangliosidosis (Morquio disease type B)
[1, 2]
.

References

1.Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Proc. Natl. Acad. Sci. U.S.A. 92, 7090-4, (1995). View articlePMID: 7624375

2.Structures and mechanisms of glycosyl hydrolases. Davies G, Henrissat B. Structure 3, 853-9, (1995). View articlePMID: 8535779

GO terms

biological process

  • None

cellular component

  • None

Cross References

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