IPR026283
Beta-galactosidase 1-like
InterPro entry
Short name | B-gal_1-like |
Overlapping homologous superfamilies | |
family relationships |
Description
This entry represents a subset of the glycosyl hydrolase 35 family, including beta-galactosidase (B-gal), B-gal-1, B-gal-1-like, B-gal-8, B-gal-17. Mammalian beta-galactosidase is a lysosomal enzyme (gene GLB1) which cleaves the terminal galactose from gangliosides, glycoproteins, and glycosaminoglycans and whose deficiency is the cause of the genetic disease Gm(1) gangliosidosis (Morquio disease type B)
[1, 2].
References
1.Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Proc. Natl. Acad. Sci. U.S.A. 92, 7090-4, (1995). View articlePMID: 7624375
2.Structures and mechanisms of glycosyl hydrolases. Davies G, Henrissat B. Structure 3, 853-9, (1995). View articlePMID: 8535779
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
Contributing Member Database Entry
- PIRSF:PIRSF006336
Representative structure
4mad: Crystal structure of beta-galactosidase C (BgaC) from Bacillus circulans ATCC 31382