IPR026382
RNA endonuclease, cap-snatching, arenaviral
InterPro entry
Short name | CapSnatch_arenavir |
domain relationships |
Description
This entry represents a domain from an RNA endonuclease region associated with cap-snatching for mRNA production by RNA viruses
[2]. This domain usually is part of a multifunctional protein, the L protein responsible for RNA-dependent RNA polymerase activity. Cap-snatching is a viral alternative to synthesizing a eukaryotic-like mRNA cap itself
[1]. This group of proteins is specific to arenavirales.
References
1.The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B. PLoS Pathog. 6, e1001038, (2010). View articlePMID: 20862324
Cross References
ENZYME
Contributing Member Database Entry
- Pfam:PF17296
Representative structure
5izh: Lassa virus L protein cap-snatching endonuclease. apo form