D
IPR026382

RNA endonuclease, cap-snatching, arenaviral

InterPro entry
Short nameCapSnatch_arenavir
domain relationships

Description

This entry represents a domain from an RNA endonuclease region associated with cap-snatching for mRNA production by RNA viruses
[2]
. This domain usually is part of a multifunctional protein, the L protein responsible for RNA-dependent RNA polymerase activity. Cap-snatching is a viral alternative to synthesizing a eukaryotic-like mRNA cap itself
[1]
. This group of proteins is specific to arenavirales.

References

1.The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B. PLoS Pathog. 6, e1001038, (2010). View articlePMID: 20862324

2.Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription. Reguera J, Weber F, Cusack S. PLoS Pathog. 6, (2010). PMID: 20862319

Cross References

Contributing Member Database Entry
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