D
IPR026470

Flavivirus envelope glycoprotein E, Stem/Anchor domain

InterPro entry
Short nameFlavi_E_Stem/Anchor_dom
Overlapping
homologous
superfamilies
 

Description

This entry describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins
[1]
.

References

1.The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion. Fritz R, Blazevic J, Taucher C, Pangerl K, Heinz FX, Stiasny K. J. Virol. 85, 4377-85, (2011). View articlePMID: 21325407

Further reading

2. A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins. Fibriansah G, Tan JL, Smith SA, de Alwis R, Ng TS, Kostyuchenko VA, Jadi RS, Kukkaro P, de Silva AM, Crowe JE, Lok SM. Nat Commun 6, 6341, (2015). View articlePMID: 25698059

3. Structural changes in dengue virus when exposed to a temperature of 37°C. Fibriansah G, Ng TS, Kostyuchenko VA, Lee J, Lee S, Wang J, Lok SM. J Virol 87, 7585-92, (2013). View articlePMID: 23637405

4. Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ. Nat. Struct. Biol. 10, 907-12, (2003). View articlePMID: 14528291

5. Immature and mature dengue serotype 1 virus structures provide insight into the maturation process. Kostyuchenko VA, Zhang Q, Tan JL, Ng TS, Lok SM. J Virol 87, 7700-7, (2013). PMID: 23637416

6. Cryo-EM structure of the mature dengue virus at 3.5-A resolution. Zhang X, Ge P, Yu X, Brannan JM, Bi G, Zhang Q, Schein S, Zhou ZH. Nat Struct Mol Biol 20, 105-10, (2013). View articlePMID: 23241927

Cross References

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