IPR026905
Protein ASX-like, PHD domain
InterPro entry
Short name | ASX-like_PHD |
Description
This entry represetnts the PHD domain, a DNA-binding domain, on the additional sex combs (ASX) and additional sex combs-like (AsxL) proteins
[1]. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context
[2].
References
1.Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family. Fisher CL, Randazzo F, Humphries RK, Brock HW. Gene 369, 109-18, (2006). View articlePMID: 16412590
2.Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. Fisher CL, Lee I, Bloyer S, Bozza S, Chevalier J, Dahl A, Bodner C, Helgason CD, Hess JL, Humphries RK, Brock HW. Dev. Biol. 337, 9-15, (2010). View articlePMID: 19833123
GO terms
Contributing Member Database Entry
- Pfam:PF13922