IPR027235
Prefoldin subunit 2
InterPro entry
Short name | PFD2 |
Overlapping homologous superfamilies | |
family relationships |
Description
This entry represents prefoldin subunit 2 (PFD2, also known as Gim4 in budding yeasts). PFD2 is part of the prefoldin heterohexamer complex (consists of two PFD-alpha type and four PFD-beta type subunits) that binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it
[1]. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for non-native proteins
[2, 3].
References
1.A novel protein complex promoting formation of functional alpha- and gamma-tubulin. Geissler S, Siegers K, Schiebel E. EMBO J. 17, 952-66, (1998). View articlePMID: 9463374
2.Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ. Cell 93, 863-73, (1998). View articlePMID: 9630229
3.S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Djouder N, Metzler SC, Schmidt A, Wirbelauer C, Gstaiger M, Aebersold R, Hess D, Krek W. Mol. Cell 28, 28-40, (2007). View articlePMID: 17936702
GO terms
biological process
molecular function
- None
cellular component
Contributing Member Database Entry
- PANTHER:PTHR13303