F
IPR027235

Prefoldin subunit 2

InterPro entry
Short namePFD2
Overlapping
homologous
superfamilies
 
Prefoldin (IPR009053)
family relationships

Description

This entry represents prefoldin subunit 2 (PFD2, also known as Gim4 in budding yeasts). PFD2 is part of the prefoldin heterohexamer complex (consists of two PFD-alpha type and four PFD-beta type subunits) that binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it
[1]
. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for non-native proteins
[2, 3]
.

References

1.A novel protein complex promoting formation of functional alpha- and gamma-tubulin. Geissler S, Siegers K, Schiebel E. EMBO J. 17, 952-66, (1998). View articlePMID: 9463374

2.Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ. Cell 93, 863-73, (1998). View articlePMID: 9630229

3.S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Djouder N, Metzler SC, Schmidt A, Wirbelauer C, Gstaiger M, Aebersold R, Hess D, Krek W. Mol. Cell 28, 28-40, (2007). View articlePMID: 17936702

GO terms

molecular function

  • None
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