IPR027442
MAP kinase activated protein kinase, C-terminal
InterPro entry
Short name | MAPKAPK_C |
Description
This superfamily represent the C-terminal domain of the MAP kinase activated protein kinases (MAPKAPKs). Proteins containing this domain include Mapkapk2 and Mapkapk3. They are mainly involved in post-transcriptional regulation of gene expression and play an role in inflammation and cancer
[1].
References
1.MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Ronkina N, Menon MB, Schwermann J, Tiedje C, Hitti E, Kotlyarov A, Gaestel M. Biochem. Pharmacol. 80, 1915-20, (2010). View articlePMID: 20599781
Cross References
ENZYME
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:4.10.1170.10
Representative structure
2okr: Crystal Structure of the P38a-MAPKAP kinase 2 Heterodimer