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IPR027463

Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains

InterPro entry
Short nameAcrB_DN_DC_subdom
Overlapping entries
 

Description

The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli, responsible for the resistance of this organism to a wide range of drugs. AcrB exists as a homotrimer, with each subunit containing 12 transmembrane (TM) helices and a large periplasmic part formed by two loops between TM helices 1 and 2 and TM helices 7 and 8. The trimer consists of three prominent domains, the TM domain, the adjacent pore domain and the TolC docking domain
[1]
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References

1.Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. PLoS Biol. 5, e7, (2007). View articlePMID: 17194213

Further reading

2. Elastic network model-based normal mode analysis reveals the conformational couplings in the tripartite AcrAB-TolC multidrug efflux complex. Wang B, Weng J, Fan K, Wang W. Proteins 79, 2936-45, (2011). View articlePMID: 21905116

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