IPR027463
Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains
InterPro entry
Short name | AcrB_DN_DC_subdom |
Overlapping entries |
Description
The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli, responsible for the resistance of this organism to a wide range of drugs. AcrB exists as a homotrimer, with each subunit containing 12 transmembrane (TM) helices and a large periplasmic part formed by two loops between TM helices 1 and 2 and TM helices 7 and 8. The trimer consists of three prominent domains, the TM domain, the adjacent pore domain and the TolC docking domain
[1].
References
1.Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. PLoS Biol. 5, e7, (2007). View articlePMID: 17194213
Further reading
2. Elastic network model-based normal mode analysis reveals the conformational couplings in the tripartite AcrAB-TolC multidrug efflux complex. Wang B, Weng J, Fan K, Wang W. Proteins 79, 2936-45, (2011). View articlePMID: 21905116
Contributing Member Database Entries
- CATH-Gene3D:G3DSA:3.30.2090.10
- SUPERFAMILY:SSF82714