IPR027495
Thiamine thiazole synthase
InterPro entry
Short name | Sti35 |
Overlapping homologous superfamilies | |
family relationships |
Description
This entry represents the thiamine thiazole synthase, which is involved in biosynthesis of the thiamine precursor thiazole in fungi and in chloroplasts. It catalyses the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. It may have additional roles in adaptation to various stress conditions and in DNA damage tolerance
[1, 2].
References
1.The Fusarium oxysporum sti35 gene functions in thiamine biosynthesis and oxidative stress response. Ruiz-Roldan C, Puerto-Galan L, Roa J, Castro A, Di Pietro A, Roncero MI, Hera C. Fungal Genet. Biol. 45, 6-16, (2008). View articlePMID: 17964830
2.Point mutation is responsible for Arabidopsis tz-201 mutant phenotype affecting thiamin biosynthesis. Papini-Terzi FS, Galhardo RS, Farias LP, Menck CF, Van Sluys MA. Plant Cell Physiol. 44, 856-60, (2003). View articlePMID: 12941878
GO terms
biological process
molecular function
- None
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entry
- HAMAP:MF_03158
Representative structure
3fpz: Saccharomyces cerevisiae THI4p is a suicide thiamin thiazole synthase