F
IPR027495

Thiamine thiazole synthase

InterPro entry
Short nameSti35
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents the thiamine thiazole synthase, which is involved in biosynthesis of the thiamine precursor thiazole in fungi and in chloroplasts. It catalyses the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. It may have additional roles in adaptation to various stress conditions and in DNA damage tolerance
[1, 2]
.

References

1.The Fusarium oxysporum sti35 gene functions in thiamine biosynthesis and oxidative stress response. Ruiz-Roldan C, Puerto-Galan L, Roa J, Castro A, Di Pietro A, Roncero MI, Hera C. Fungal Genet. Biol. 45, 6-16, (2008). View articlePMID: 17964830

2.Point mutation is responsible for Arabidopsis tz-201 mutant phenotype affecting thiamin biosynthesis. Papini-Terzi FS, Galhardo RS, Farias LP, Menck CF, Van Sluys MA. Plant Cell Physiol. 44, 856-60, (2003). View articlePMID: 12941878

GO terms

molecular function

  • None

cellular component

  • None

Cross References

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