IPR027555
tRNA (Mo5U34)-methyltransferase-like
InterPro entry
Short name | Mo5U34_MeTrfas-like |
Overlapping homologous superfamilies | |
family relationships |
Description
Proteins in this entry include bacterial tRNA U34 carboxymethyltransferases and some methyltransferases from soil and rhizosphere bacteria. tRNA U34 carboxymethyltransferase ComB catalyses the conversion of 5-hydroxyuridine (ho5U) to uridine-5-oxyacetic acid (cmo5U) at the wobble position (34) of tRNA
[2, 3]. cmo5U is a modified nucleoside that is apparently necessary for the efficient decoding of G-ending Pro, Ala, and Val codons in these organisms
[1].
References
1.The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons. Nasvall SJ, Chen P, Bjork GR. RNA 13, 2151-64, (2007). View articlePMID: 17942742
2.The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. Nasvall SJ, Chen P, Bjork GR. RNA 10, 1662-73, (2004). View articlePMID: 15383682
3.Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC. Nature 498, 123-6, (2013). View articlePMID: 23676670
Cross References
ENZYME
Genome Properties
Contributing Member Database Entry
- Pfam:PF08003
Representative structure
4p7c: Crystal structure of putative methyltransferase from Pseudomonas syringae pv. tomato