F
IPR027555

tRNA (Mo5U34)-methyltransferase-like

InterPro entry
Short nameMo5U34_MeTrfas-like
Overlapping
homologous
superfamilies
 
family relationships

Description

Proteins in this entry include bacterial tRNA U34 carboxymethyltransferases and some methyltransferases from soil and rhizosphere bacteria. tRNA U34 carboxymethyltransferase ComB catalyses the conversion of 5-hydroxyuridine (ho5U) to uridine-5-oxyacetic acid (cmo5U) at the wobble position (34) of tRNA
[2, 3]
. cmo5U is a modified nucleoside that is apparently necessary for the efficient decoding of G-ending Pro, Ala, and Val codons in these organisms
[1]
.

References

1.The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons. Nasvall SJ, Chen P, Bjork GR. RNA 13, 2151-64, (2007). View articlePMID: 17942742

2.The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. Nasvall SJ, Chen P, Bjork GR. RNA 10, 1662-73, (2004). View articlePMID: 15383682

3.Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC. Nature 498, 123-6, (2013). View articlePMID: 23676670

Cross References

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