IPR027936
Ephrin receptor, transmembrane domain
InterPro entry
Short name | Eph_TM |
Description
This entry represents the left-handed dimer transmembrane domain of Ephrin receptors. This domain oligomerises and is important for the active signalling process
[1].
Proteins containing this domain include the ephrin type-A and type-B receptors. Ephrin receptors (Ephs) are a group of receptor tyrosine kinases that are activated in response to binding ephrin ligands residing on adjacent cells
[2]. This binding leads to contact-dependent bidirectional signaling into neighbouring cells
[2].
References
1.Left-handed dimer of EphA2 transmembrane domain: Helix packing diversity among receptor tyrosine kinases. Bocharov EV, Mayzel ML, Volynsky PE, Mineev KS, Tkach EN, Ermolyuk YS, Schulga AA, Efremov RG, Arseniev AS. Biophys. J. 98, 881-9, (2010). View articlePMID: 20197042
2.Mechanisms and functions of Eph and ephrin signalling. Kullander K, Klein R. Nat. Rev. Mol. Cell Biol. 3, 475-86, (2002). View articlePMID: 12094214
Cross References
ENZYME
Contributing Member Database Entry
- Pfam:PF14575