IPR028258
Exocyst complex component Sec3, PIP2-binding N-terminal domain
InterPro entry
Short name | Sec3-PIP2_bind |
Description
This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the targeting and tethering of post-Golgi secretory vesicles to fusion sites on the plasma membrane prior to SNARE-mediated fusion. This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the phosphatidylinositol 4,5-bisphosphate (PIP2) head group are conserved. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables
[1].
References
1.Fission yeast Sec3 and Exo70 are transported on actin cables and localize the exocyst complex to cell poles. Bendezu FO, Vincenzetti V, Martin SG. PLoS ONE 7, e40248, (2012). View articlePMID: 22768263
Representative structure
3hie: Structure of the membrane-binding domain of the Sec3 subunit of the Exocyst complex