IPR028267
Rapamycin-insensitive companion of mTOR, N-terminal domain
InterPro entry
Short name | Pianissimo_N |
Overlapping homologous superfamilies |
Description
The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2
[2]. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling
[1]. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility
[3].
This domain is the N-terminal conserved section that may include several individual domains.
References
1.mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. Julien LA, Carriere A, Moreau J, Roux PP. Mol. Cell. Biol. 30, 908-21, (2010). View articlePMID: 19995915
2.Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Curr. Biol. 14, 1296-302, (2004). View articlePMID: 15268862
3.mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Masri J, Bernath A, Martin J, Jo OD, Vartanian R, Funk A, Gera J. Cancer Res. 67, 11712-20, (2007). View articlePMID: 18089801