F
IPR028355

Estrogen receptor beta/gamma

InterPro entry
Short nameER-beta/gamma
family relationships

Description

There are three distinct estrogen receptor (ER) subtypes: ER-alpha, ER-beta, and a third type (ER-gamma) identified in teleost fish
[1]
. This entry represents the subtypes beta and gamma.

ER-beta binds estrogens and activates expression of reporter genes containing estrogen response element (ERE). ER-beta differs from ER-alpha in its ligand binding affinities to both natural and synthetic estrogens, tissue distributions, and transactivation properties
[2, 3]
. The presence of different ER explains the seemingly contradictory actions of estrogens in certain target tissues, and illustrates the complexity of estrogenic action.

.

References

1.Identification of a third distinct estrogen receptor and reclassification of estrogen receptors in teleosts. Hawkins MB, Thornton JW, Crews D, Skipper JK, Dotte A, Thomas P. Proc. Natl. Acad. Sci. U.S.A. 97, 10751-6, (2000). View articlePMID: 11005855

2.Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA. Endocrinology 138, 863-70, (1997). View articlePMID: 9048584

3.Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS. Science 277, 1508-10, (1997). View articlePMID: 9278514

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