F
IPR028366

Phosphate transport system protein PhoU

InterPro entry
Short nameP_transport_PhoU
Overlapping
homologous
superfamilies
 

Description

PhoU is a negative regulator in Pho regulon which plays a key role in phosphate homeostasis
[4, 3]
. Members of the Pho regulon include alkaline phosphatase (AP), the PhoB-PhoR proteins and the PstSCAB and PhoU proteins. PhoU is encoded together with proteins of the phosphate-specific transport (Pst) system in the polycistronic pstSCAB-phoU operon. PhoU is essential for the repression of the Pho regulon at high phosphate conditions by a mechanism which is not fully understood. It has been proposed that PhoU may not only control the abundance of the PstSCAB2 transporter through the PhoBR two-component signaling pathway, but also control its activity
[2]
. PhoU is known to interact with PhoR and PstB, and it may be involved in the formation of a signaling complex at the cytoplasmic membrane that responds to environmental Pi levels
[1]
.

References

1.The PhoU protein from Escherichia coli interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane. Gardner SG, Johns KD, Tanner R, McCleary WR. J. Bacteriol. 196, 1741-52, (2014). View articlePMID: 24563032

2.Employment of a promoter-swapping technique shows that PhoU modulates the activity of the PstSCAB2 ABC transporter in Escherichia coli. Rice CD, Pollard JE, Lewis ZT, McCleary WR. Appl. Environ. Microbiol. 75, 573-82, (2009). View articlePMID: 19047379

3.Transcript and protein level analyses of the interactions among PhoB, PhoR, PhoU and CreC in response to phosphate starvation in Escherichia coli. Baek JH, Kang YJ, Lee SY. FEMS Microbiol. Lett. 277, 254-9, (2007). View articlePMID: 18031348

4.Regulation of the phosphate regulon in Escherichia coli K-12: regulation of the negative regulatory gene phoU and identification of the gene product. Nakata A, Amemura M, Shinagawa H. J. Bacteriol. 159, 979-85, (1984). PMID: 6090402

GO terms

Cross References

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