H
IPR029001

Inosine triphosphate pyrophosphatase-like

InterPro entry
Short nameITPase-like_fam
Overlapping entries
 
RdgB/HAM1 (IPR002637)

Description

This entry represents the inosine triphosphate pyrophosphatase (ITPase)-like proteins. Members in this family include NTPases, such as Ham1-like protein (non-canonical purine NTP pyrophosphatase) and non-canonical purine NTP phosphatase (YjjX-like), Maf-like proteins and PRRC1.

Non-canonical purine NTP phosphatases are prokaryotic phosphatases that hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives
[2]
.

Ham1 is a pyrophosphatase that hydrolyses the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives
[1]
.

Maf proteins exhibit nucleotide pyrophosphatase activity against canonical and modified nucleotides
[4]
. Proline-rich and coiled-coil-containing protein 1 (PRRC1) is a Golgi-associated protein of unknown function
[3]
.

References

1.Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism. Davies O, Mendes P, Smallbone K, Malys N. BMB Rep 45, 259-64, (2012). PMID: 22531138

2.Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis. Zheng J, Singh VK, Jia Z. Structure 13, 1511-20, (2005). View articlePMID: 16216582

3.Structural analysis and expression profile of a novel gene on chromosome 5q23 encoding a Golgi-associated protein with six splice variants, and involved within the 5q deletion of a Ph(-) CML patient. Kamakari S, Roussou A, Jefferson A, Ragoussis I, Anagnou NP. Leuk. Res. 29, 17-31, (2005). View articlePMID: 15541471

4.Biochemical and structural studies of conserved Maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Tchigvintsev A, Tchigvintsev D, Flick R, Popovic A, Dong A, Xu X, Brown G, Lu W, Wu H, Cui H, Dombrowski L, Joo JC, Beloglazova N, Min J, Savchenko A, Caudy AA, Rabinowitz JD, Murzin AG, Yakunin AF. Chem. Biol. 20, 1386-98, (2013). View articlePMID: 24210219

Cross References

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