H
IPR029070

Chitinase insertion domain superfamily

InterPro entry
Short nameChitinase_insertion_sf
Overlapping entries
 

Description

This superfamily represents the chitinase insertion domain (CID) that is found in chitinases or chitinase-like proteins. It is composed of five or six anti-parallel β-strands and one α-helix and it inserts between the seventh α-helix and seventh β-strand of the TIM barrel
[1]
. The CID domain forms a wall alongside the TIM barrel substrate-binding cleft of chitinase which increases the depth of the cleft. Family 18 chitinases (also known as glycosyl hydrolase 18 family) can be classified into three subfamilies: A, B, and C. The CID domain can be found in the subfamily A, but is absent in the subfamily B
[1]
.

References

1.Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-binding. Li H, Greene LH. PLoS ONE 5, e8654, (2010). View articlePMID: 20084296

Cross References

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