IPR029070
Chitinase insertion domain superfamily
InterPro entry
Short name | Chitinase_insertion_sf |
Overlapping entries |
Description
This superfamily represents the chitinase insertion domain (CID) that is found in chitinases or chitinase-like proteins. It is composed of five or six anti-parallel β-strands and one α-helix and it inserts between the seventh α-helix and seventh β-strand of the TIM barrel
[1]. The CID domain forms a wall alongside the TIM barrel substrate-binding cleft of chitinase which increases the depth of the cleft. Family 18 chitinases (also known as glycosyl hydrolase 18 family) can be classified into three subfamilies: A, B, and C. The CID domain can be found in the subfamily A, but is absent in the subfamily B
[1].
References
1.Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-binding. Li H, Greene LH. PLoS ONE 5, e8654, (2010). View articlePMID: 20084296
Cross References
Contributing Member Database Entries
- CATH-Gene3D:G3DSA:3.10.50.10
- SUPERFAMILY:SSF54556