F
IPR029515

LAR-interacting protein, Liprin

InterPro entry
Short nameLiprin

Description

This entry represents liprin family from vertebrates and invertebrates.

Liprin was originally identified as binding partners of the receptor protein tyrosine phosphatase LAR (leukocyte common antigen-related), which functions in axon guidance and mammary gland development
[1]
. In vertebrates, there are two families of liprins, liprin-alpha and liprin-beta, which have four (alpha1-4) and two (beta1-2) members. In C. elegans and Drosophila, there are only one liprin-alpha (known as Syd-2 and Dliprin-alpha) and one liprin-beta. Another liprin family member, liprin-gamma, has also been identified in Drosophila
[4]
. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains
[3]
. The N-terminal coiled coils of liprin-alpha mediate interactions with adapter proteins at the presynaptic active zone, while the SAM repeats bind proteins such as LAR receptor tyrosine phosphatase
[2]
.

References

1.Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M. J. Biol. Chem. 273, 15611-20, (1998). View articlePMID: 9624153

2.The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly. Taru H, Jin Y. J. Neurosci. 31, 16261-8, (2011). View articlePMID: 22072677

3.Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures. Wei Z, Zheng S, Spangler SA, Yu C, Hoogenraad CC, Zhang M. Mol. Cell 43, 586-98, (2011). View articlePMID: 21855798

4.Three Drosophila liprins interact to control synapse formation. Astigarraga S, Hofmeyer K, Farajian R, Treisman JE. J. Neurosci. 30, 15358-68, (2010). View articlePMID: 21084592

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.