F
IPR029703

DNA polymerase epsilon catalytic subunit

InterPro entry
Short namePOL2
family relationships

Description

DNA polymerase epsilon catalytic subunit (also known as POL2) is a catalytic subunit of DNA polymerase epsilon, which is a a high-fidelity polymerase participating in chromosomal DNA replication
[1]
. It contains both polymerase and 3'-5'-exonuclease domains
[1]
. Its 3'-5'-exonuclease domain ensures a particularly low error rate
[3]
. POL2 also plays a role in DNA repair and is linked to cancer
[3]
. Its structure has been solved
[2]
.

References

1.Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ. Hogg M, Osterman P, Bylund GO, Ganai RA, Lundstrom EB, Sauer-Eriksson AE, Johansson E. Nat. Struct. Mol. Biol. 21, 49-55, (2014). View articlePMID: 24292646

2.Crystal structure of yeast DNA polymerase ε catalytic domain. Jain R, Rajashankar KR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. PLoS ONE 9, e94835, (2014). View articlePMID: 24733111

3.Replicative DNA polymerase mutations in cancer. Heitzer E, Tomlinson I. Curr. Opin. Genet. Dev. 24, 107-13, (2014). View articlePMID: 24583393

GO terms

Cross References

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