IPR029703
DNA polymerase epsilon catalytic subunit
InterPro entry
Short name | POL2 |
family relationships |
Description
DNA polymerase epsilon catalytic subunit (also known as POL2) is a catalytic subunit of DNA polymerase epsilon, which is a a high-fidelity polymerase participating in chromosomal DNA replication
[1]. It contains both polymerase and 3'-5'-exonuclease domains
[1]. Its 3'-5'-exonuclease domain ensures a particularly low error rate
[3]. POL2 also plays a role in DNA repair and is linked to cancer
[3]. Its structure has been solved
[2].
References
1.Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ. Hogg M, Osterman P, Bylund GO, Ganai RA, Lundstrom EB, Sauer-Eriksson AE, Johansson E. Nat. Struct. Mol. Biol. 21, 49-55, (2014). View articlePMID: 24292646
2.Crystal structure of yeast DNA polymerase ε catalytic domain. Jain R, Rajashankar KR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK. PLoS ONE 9, e94835, (2014). View articlePMID: 24733111
3.Replicative DNA polymerase mutations in cancer. Heitzer E, Tomlinson I. Curr. Opin. Genet. Dev. 24, 107-13, (2014). View articlePMID: 24583393
GO terms
biological process
cellular component
Cross References
Contributing Member Database Entry
- PANTHER:PTHR10670