F
IPR030547

DNA repair protein XRCC2

InterPro entry
Short nameXRCC2
Overlapping
homologous
superfamilies
 

Description

DNA repair protein XRCC2 is a RAD51 paralogue. In humans, it is part of the protein complex BCDX2 (contains RAD51B, RAD51C, RAD51D, and XRCC2), which acts in the BRCA1-BRCA2-dependent homologous recombination pathway
[1, 2]
. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA
[1]
. Interestingly, XRCC2 and other homologous recombination proteins are associated with centrosomes and are required for mitotic stability
[3]
.

References

1.Identification and purification of two distinct complexes containing the five RAD51 paralogs. Masson JY, Tarsounas MC, Stasiak AZ, Stasiak A, Shah R, McIlwraith MJ, Benson FE, West SC. Genes Dev. 15, 3296-307, (2001). View articlePMID: 11751635

2.Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Chun J, Buechelmaier ES, Powell SN. Mol. Cell. Biol. 33, 387-95, (2013). View articlePMID: 23149936

3.Homologous recombination proteins are associated with centrosomes and are required for mitotic stability. Cappelli E, Townsend S, Griffin C, Thacker J. Exp. Cell Res. 317, 1203-13, (2011). View articlePMID: 21276791

GO terms

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