F
IPR030675

Lipid binding protein BPI/LBP

InterPro entry
Short nameBPI/LBP
family relationships

Description

This entry represents the bactericidal permeability-increasing protein (BPI) and the lipopolysaccharide-binding protein (LBP). The crystal structures of BPI and LBP are similar
[1]
, and they may represent a common gene family of lipid-binding proteins
[3]
.

In mammals, LBP and BPI mediate the biological effects of LPS (lipopolysaccharide), a glycolipid present in the outer membrane of Gram-negative bacteria. LBP is a plasma protein that enhances the inflammatory response to LPS, whereas BPI is found in lysosomal granules of polymorphonuclear neutrophils, is bactericidal, and neutralises the toxic effects of LPS
[2, 4]
.

References

1.Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Beamer LJ, Carroll SF, Eisenberg D. Science 276, 1861-4, (1997). View articlePMID: 9188532

2.Prospects for use of recombinant BPI in the treatment of gram-negative bacterial infections. Elsbach P, Weiss J. Infect Agents Dis 4, 102-9, (1995). PMID: 7613727

3.Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins. Kirschning CJ, Au-Young J, Lamping N, Reuter D, Pfeil D, Seilhamer JJ, Schumann RR. Genomics 46, 416-25, (1997). View articlePMID: 9441745

4.Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. Wilde CG, Seilhamer JJ, McGrogan M, Ashton N, Snable JL, Lane JC, Leong SR, Thornton MB, Miller KL, Scott RW. J. Biol. Chem. 269, 17411-6, (1994). PMID: 7517398

Further reading

5. Lipopolysaccharide binding protein participation in cellular activation by LPS. Su GL, Simmons RL, Wang SC. Crit. Rev. Immunol. 15, 201-14, (1995). PMID: 8834448

GO terms

biological process

  • None

molecular function

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