F
IPR030687

Sterol O-acyltransferase, metazoa

InterPro entry
Short nameSterol_acyltranf_meta
family relationships

Description

Sterol O-acyltransferase 1 (SOAT1; also known as ACAT1) and sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) both play a role in the formation of fatty acid-cholesterol esters
[4]
. Cholesterol esters are less soluble in membranes than cholesterol and accumulate in atherosclerotic lesions, making ACAT inhibitors a pharmacological target against atherosclerosis
[5, 3]
. SOAT1 is present in steroidogenic tissues, kidneys, sebaceous glands and macrophages. SOAT2 is expressed predominantly in the liver and small intestine
[2, 1]
.

References

1.Differential expression of ACAT1 and ACAT2 among cells within liver, intestine, kidney, and adrenal of nonhuman primates. Lee RG, Willingham MC, Davis MA, Skinner KA, Rudel LL. J. Lipid Res. 41, 1991-2001, (2000). PMID: 11108732

2.ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization. Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV Jr. J. Biol. Chem. 273, 26755-64, (1998). View articlePMID: 9756919

3.Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver. Lopez AM, Posey KS, Turley SD. Biochem. Biophys. Res. Commun. 454, 162-166, (2014). PMID: 25450374

4.Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. Oelkers P, Behari A, Cromley D, Billheimer JT, Sturley SL. J. Biol. Chem. 273, 26765-71, (1998). View articlePMID: 9756920

5.Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Chang C, Dong R, Miyazaki A, Sakashita N, Zhang Y, Liu J, Guo M, Li BL, Chang TY. Acta Biochim. Biophys. Sin. (Shanghai) 38, 151-6, (2006). View articlePMID: 16518538

GO terms

Cross References

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