F
IPR030798

Arfaptin family

InterPro entry
Short nameArfaptin_fam
Overlapping
homologous
superfamilies
 

Description

This family consists of Arfaptin-1, Arfaptin-2, and protein kinase C-binding protein 1 (PICK1). They all contain a Bin/amphiphysin/Rvs (BAR) domain
[5]
. BAR-domain-containing proteins are key players in membrane dynamics as their crescent shape allows them to sense or generate curvature on lipid bilayers
[3]
.

Arfaptin-1 and 2 have been shown to interact with Arf GTPases and Arf-like 1 (Arl1). They are recruited to trans-Golgi membranes through interaction with Arl1
[2]
.

In neurons, PICK1 forms homodimers and serves as one of the scaffolding proteins that interacts with AMPA receptors and regulates their trafficking in synaptic plasticity
[1]
. In pancreatic beta cells, it forms heteromeric BAR-domain complexes with another cytosolic lipid-binding protein, ICA69. Together they are key regulators of the formation and maturation of insulin granules
[4]
.

References

1.Threonine 82 at the PDZ domain of PICK1 is critical for AMPA receptor interaction and localization. Shao X, Zhu L, Wang Y, Lu Y, Wang W, Zhu J, Shen Y, Xia J, Luo J. Neurochem. Int. 56, 962-70, (2010). View articlePMID: 20403402

2.Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. Nakamura K, Man Z, Xie Y, Hanai A, Makyio H, Kawasaki M, Kato R, Shin HW, Nakayama K, Wakatsuki S. J. Biol. Chem. 287, 25478-89, (2012). View articlePMID: 22679020

3.Membrane curvature and mechanisms of dynamic cell membrane remodelling. McMahon HT, Gallop JL. Nature 438, 590-6, (2005). View articlePMID: 16319878

4.PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KK, Xu A, Lee KM, Jiang L, Xia J. PLoS Biol. 11, e1001541, (2013). View articlePMID: 23630453

5.The BAR-domain family of proteins: a case of bending and binding? Habermann B. EMBO Rep. 5, 250-5, (2004). View articlePMID: 14993925

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