D
IPR032073

Fibronectin type III domain-containing protein 5, C-terminal domain

InterPro entry
Short nameFNDC5_C

Description

This domain is found in fibronectin type III domain-containing protein 5 (FNDC5). FNDC5 is cleaved into Irisin, a putative myokin that stimulates white-to-brown fat conversion in mice
[2]
, though this role is disputed in humans
[3, 4]
. This domain is found C-terminal to the irisin domain
[1]
.

References

1.The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. Schumacher MA, Chinnam N, Ohashi T, Shah RS, Erickson HP. J. Biol. Chem. 288, 33738-44, (2013). View articlePMID: 24114836

2.A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM. Nature 481, 463-8, (2012). View articlePMID: 22237023

3.Browning of white fat: does irisin play a role in humans? Elsen M, Raschke S, Eckel J. J. Endocrinol. 222, R25-38, (2014). View articlePMID: 24781257

4.Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin. Kristof E, Doan-Xuan QM, Bai P, Bacso Z, Fesus L. Sci Rep 5, 12540, (2015). View articlePMID: 26212086

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