D
IPR032354

FOXP, coiled-coil domain

InterPro entry
Short nameFOXP-CC

Description

This coiled-coil domain, approximately 60-70 residues in length, is mainly found in Forkhead box proteins from animals
[1]
. It modulates the dimeric associations of FOXP transcription factors. Several mutations found in this domain have been linked to the IPEX syndrome (immunodysregulation polyendocrinopathy enteropathy X-linked syndrome)
[2]
.

References

1.Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues. Lu MM, Li S, Yang H, Morrisey EE. Mech. Dev. 119 Suppl 1, S197-202, (2002). View articlePMID: 14516685

2.Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z, Wu SL, Cai Z, Zhang H, Karger BL, Hancock WW, Wells AD, Zhou Z, Greene MI. 1, 665-75, (2012). View articlePMID: 22813742

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