IPR032415
TRPM, tetramerisation domain
InterPro entry
Short name | TRPM_tetra |
Overlapping homologous superfamilies |
Description
This entry represents a short anti-parallel coiled-coil tetramerisation domain of the transient receptor potential cation channel subfamily M member proteins 1/3/6/7. It is held together by extensive core packing and interstrand polar interactions. Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. The presence of cytoplasmic domains that direct channel assembly appears to be a feature of many voltage-gated ion channel superfamily members
[1].
References
1.X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. Fujiwara Y, Minor DL Jr. J. Mol. Biol. 383, 854-70, (2008). View articlePMID: 18782578
GO terms
Cross References
ENZYME
Contributing Member Database Entry
- Pfam:PF16519