D
IPR032415

TRPM, tetramerisation domain

InterPro entry
Short nameTRPM_tetra
Overlapping
homologous
superfamilies
 

Description

This entry represents a short anti-parallel coiled-coil tetramerisation domain of the transient receptor potential cation channel subfamily M member proteins 1/3/6/7. It is held together by extensive core packing and interstrand polar interactions. Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. The presence of cytoplasmic domains that direct channel assembly appears to be a feature of many voltage-gated ion channel superfamily members
[1]
.

References

1.X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil. Fujiwara Y, Minor DL Jr. J. Mol. Biol. 383, 854-70, (2008). View articlePMID: 18782578

GO terms

molecular function

  • None

cellular component

  • None

Cross References

Contributing Member Database Entry
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