D
IPR032456

CAAX prenyl protease 1, N-terminal

InterPro entry
Short namePeptidase_M48_N

Description

This entry represents the N-terminal five transmembrane α-helices domain of CAAX prenyl protease 1 (also known as Ste24 in budding yeast). Ste24 is a zinc metalloprotease catalysing two proteolytic steps in the maturation of yeast mating pheromone a-factor
[1]
. The structures of Ste24 and its human homologue, ZMPSTE24, have been revealed
[1, 2]
.

References

1.Structure of the integral membrane protein CAAX protease Ste24p. Pryor EE Jr, Horanyi PS, Clark KM, Fedoriw N, Connelly SM, Koszelak-Rosenblum M, Zhu G, Malkowski MG, Wiener MC, Dumont ME. Science 339, 1600-4, (2013). View articlePMID: 23539602

2.The structural basis of ZMPSTE24-dependent laminopathies. Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP. Science 339, 1604-7, (2013). View articlePMID: 23539603

Cross References

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