IPR032673
DNA photolyase class 2, conserved site
InterPro entry
Short name | DNA_photolyase_2_CS |
Description
The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks. The photolyasess use the blue light for light-driven electron transfer to repair UV-damaged DNA, while the cryptochromes are blue-light photoreceptors involved in the circadian clock for plants and animals
[3, 1]. On the basis of the primary structure, the cryptochrome/DNA photolyase family can be grouped into two classes
[2]. The first class contains cryptochromes and DNA photolyases from eubacteria, archaea, fungi, animals and plants. The second class contains DNA photolyases from prokaryotes, plants and animals.
This entry represents a number of conserved sequence regions found in the C-terminal region of the class 2 DNA photolyases.
References
1.Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes. Mei Q, Dvornyk V. PLoS ONE 10, e0135940, (2015). View articlePMID: 26352435
2.A new class of DNA photolyases present in various organisms including aplacental mammals. Yasui A, Eker AP, Yasuhira S, Yajima H, Kobayashi T, Takao M, Oikawa A. EMBO J. 13, 6143-51, (1994). View articlePMID: 7813451
3.Binding of Substrate Locks the Electrochemistry of CRY-DASH into DNA Repair. Gindt YM, Messyasz A, Jumbo PI. Biochemistry 54, 2802-5, (2015). View articlePMID: 25910181
Cross References
ENZYME