D
IPR032731

Arabinosyltransferase, C-terminal

InterPro entry
Short nameArabino_trans_C
Overlapping
homologous
superfamilies
 

Description

Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol
[1]
.

This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate
[2]
.

References

1.The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM. Proc. Natl. Acad. Sci. U.S.A. 93, 11919-24, (1996). View articlePMID: 8876238

2.The C-terminal domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC is a lectin-like carbohydrate binding module. Alderwick LJ, Lloyd GS, Ghadbane H, May JW, Bhatt A, Eggeling L, Futterer K, Besra GS. PLoS Pathog. 7, e1001299, (2011). View articlePMID: 21383969

Cross References

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