S
IPR033128

Adenylosuccinate synthase, active site

InterPro entry
Short nameAdenylosuccin_syn_Lys_AS

Description

Adenylosuccinate synthetase (
6.3.4.4
) plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle.

This entry represents a conserved region containing a lysine residue known to be essential for the enzyme's activity
[1]
.

References

1.Refined crystal structures of unligated adenylosuccinate synthetase from Escherichia coli. Silva MM, Poland BW, Hoffman CR, Fromm HJ, Honzatko RB. J. Mol. Biol. 254, 431-46, (1995). View articlePMID: 7490761

Cross References

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