F
IPR033270

VPRBP/DCAF1 family

InterPro entry
Short nameVPRBP/DCAF1

Description

This entry represents the VPRBP/DCAF1 family, whose members include protein VPRBP from mammals
[3]
, protein mahjong form fruit flies
[2]
and DCAF1 from worms and plants
[1]
. They are the substrate recognition component of the E3 ubiquitin-protein ligase complex.

References

1.Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, Feng S, Chen F, Chen H, Wang J, McCall C, Xiong Y, Deng XW. Plant Cell 20, 1437-55, (2008). View articlePMID: 18552200

2.Involvement of Lgl and Mahjong/VprBP in cell competition. Tamori Y, Bialucha CU, Tian AG, Kajita M, Huang YC, Norman M, Harrison N, Poulton J, Ivanovitch K, Disch L, Liu T, Deng WM, Fujita Y. PLoS Biol. 8, e1000422, (2010). View articlePMID: 20644714

3.Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N. Nature 443, 590-3, (2006). View articlePMID: 16964240

Further reading

4. VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. Kim K, Kim JM, Kim JS, Choi J, Lee YS, Neamati N, Song JS, Heo K, An W. Mol. Cell 52, 459-67, (2013). View articlePMID: 24140421

5. EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Lee JM, Lee JS, Kim H, Kim K, Park H, Kim JY, Lee SH, Kim IS, Kim J, Lee M, Chung CH, Seo SB, Yoon JB, Ko E, Noh DY, Kim KI, Kim KK, Baek SH. Mol. Cell 48, 572-86, (2012). View articlePMID: 23063525

GO terms

molecular function

  • None

cellular component

  • None

Cross References

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