IPR033509
E3 ubiquitin-protein ligase RNF146
InterPro entry
Short name | RNF146 |
Overlapping homologous superfamilies |
Description
References
1.RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. Zhang Y, Liu S, Mickanin C, Feng Y, Charlat O, Michaud GA, Schirle M, Shi X, Hild M, Bauer A, Myer VE, Finan PM, Porter JA, Huang SM, Cong F. Nat. Cell Biol. 13, 623-9, (2011). View articlePMID: 21478859
2.Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal. DaRosa PA, Wang Z, Jiang X, Pruneda JN, Cong F, Klevit RE, Xu W. Nature 517, 223-6, (2015). View articlePMID: 25327252
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entry
- PANTHER:PTHR13417
Representative structure
4qpl: Crystal structure of RNF146(RING-WWE)/UbcH5a/iso-ADPr complex