F
IPR033680

Elongation of very long chain fatty acids protein 2

InterPro entry
Short nameELOVL2
family relationships

Description

Elongation of very long chain fatty acids protein 2 (ELOVL2, also known as very long chain fatty acid elongase 2) is a component of the the long-chain fatty acids elongation cycle
[2]
. It is a transmembrane enzyme in the endoplasmic reticulum that adds two carbons per cycle to long- and very long-chain fatty acids acting on polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. It catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA
[1]
.

References

1.ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A. Proc. Natl. Acad. Sci. U.S.A. 107, 18439-44, (2010). View articlePMID: 20937905

2.The structural basis of fatty acid elongation by the ELOVL elongases. Nie L, Pascoa TC, Pike ACW, Bushell SR, Quigley A, Ruda GF, Chu A, Cole V, Speedman D, Moreira T, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Love JD, Brennan PE, Carpenter EP. Nat Struct Mol Biol 28, 512-520, (2021). View articlePMID: 34117479

GO terms

Cross References

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