F
IPR033867

Ribosome assembly factor Mrt4

InterPro entry
Short nameMrt4
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry represents the ribosome assembly factor mrt4 and related proteins. Mrt4 is a ribosomal stalk protein uL10 (also known as P0 or Rpp0) paralogue involved in ribosome biogenesis and mRNA turnover
[4, 3]
. uL10 (P0) is cytoplasmic and is present in cytoplasmic pre-60S particles and mature 60S subunits. Mrt4, however, is nuclear and has been identified in pre-60S ribosome complexes but not in mature 60S subunits, suggesting that it binds ribosomes at an early stage of assembly in the nucleolus and during assembly it is exchanged for uL10 (P0). The dual-specificity phosphatase Yvh1 is required for Mrt4 displacement from the pre-60S subunit
[2]
. P0 is required for the release of Mrt4 and exchanges with this factor at the cytoplasm
[1]
.

References

1.Role and dynamics of the ribosomal protein P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae. Rodriguez-Mateos M, Garcia-Gomez JJ, Francisco-Velilla R, Remacha M, de la Cruz J, Ballesta JP. Nucleic Acids Res. 37, 7519-32, (2009). View articlePMID: 19789271

2.Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0. Lo KY, Li Z, Wang F, Marcotte EM, Johnson AW. J. Cell Biol. 186, 849-62, (2009). View articlePMID: 19797078

3.Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover. Zuk D, Belk JP, Jacobson A. Genetics 153, 35-47, (1999). PMID: 10471698

4.Composition and functional characterization of yeast 66S ribosome assembly intermediates. Harnpicharnchai P, Jakovljevic J, Horsey E, Miles T, Roman J, Rout M, Meagher D, Imai B, Guo Y, Brame CJ, Shabanowitz J, Hunt DF, Woolford JL Jr. Mol. Cell 8, 505-15, (2001). View articlePMID: 11583614

GO terms

molecular function

  • None

cellular component

  • None
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