D
IPR034169

NifX-like domain

InterPro entry
Short nameNifX-like
Overlapping
homologous
superfamilies
 
domain relationships

Description

NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein is part of the nitrogen fixation gene cluster in nitrogen-fixing bacteria and has sequence similarity to other members of the cluster
[3, 2]
. This domain is also found C-terminal in NifY, which is also part of the nif cluster
[1]
.

References

1.Physical and genetic map of the major nif gene cluster from Azotobacter vinelandii. Jacobson MR, Brigle KE, Bennett LT, Setterquist RA, Wilson MS, Cash VL, Beynon J, Newton WE, Dean DR. J. Bacteriol. 171, 1017-27, (1989). View articlePMID: 2644218

2.Requirement of NifX and other nif proteins for in vitro biosynthesis of the iron-molybdenum cofactor of nitrogenase. Shah VK, Rangaraj P, Chatterjee R, Allen RM, Roll JT, Roberts GP, Ludden PW. J. Bacteriol. 181, 2797-801, (1999). PMID: 10217770

3.DNA sequence and genetic analysis of the Rhodobacter capsulatus nifENX gene region: homology between NifX and NifB suggests involvement of NifX in processing of the iron-molybdenum cofactor. Moreno-Vivian C, Schmehl M, Masepohl B, Arnold W, Klipp W. Mol. Gen. Genet. 216, 353-63, (1989). View articlePMID: 2747620

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