IPR034185
Site-1 peptidase catalytic domain
InterPro entry
Short name | Site-1_peptidase_cat_dom |
Overlapping homologous superfamilies | |
domain relationships |
Description
Site-1 peptidase (also known as SKI-1 or type I membrane-bound subtilisin-kexin-isoenzyme; MEROPS identifier S08.063) is a secretory Ca2+-dependent serine endopeptidase and a member of the subtilisin family S8, subfamily S8A
[4]. It cleaves at nonbasic residues: Thr, Leu, and Lys. Site-1 peptidase plays a critical role in the regulation of the synthesis and metabolism of cholesterol and fatty acid metabolism
[1].
The subtilisin family is one of the largest serine peptidase families characterised to date. Over 200 subtilises are presently known, more than 170 of which with their complete amino acid sequence
[3]. It is widespread, being found in eubacteria, archaebacteria, eukaryotes and viruses
[2]. The vast majority of the family are endopeptidases, although there is an exopeptidase, tripeptidyl peptidase
[2, 4]. Structures have been determined for several members of the subtilisin family: they exploit the same catalytic triad as the chymotrypsins, although the residues occur in a different order (HDS in chymotrypsin and DHS in subtilisin), but the structures show no other similarity
[2, 4]. Some subtilisins are mosaic proteins, while others contain N- and C-terminal extensions that show no sequence similarity to any other known protein
[2].
References
1.The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. Seidah NG, Sadr MS, Chretien M, Mbikay M. J. Biol. Chem. 288, 21473-81, (2013). View articlePMID: 23775089
2.Families of serine peptidases. Rawlings ND, Barrett AJ. Meth. Enzymol. 244, 19-61, (1994). View articlePMID: 7845208
3.Subtilases: the superfamily of subtilisin-like serine proteases. Siezen RJ, Leunissen JA. Protein Sci. 6, 501-23, (1997). View articlePMID: 9070434
4.Evolutionary families of peptidases. Rawlings ND, Barrett AJ. Biochem. J. 290 ( Pt 1), 205-18, (1993). View articlePMID: 8439290
Cross References
ENZYME
Contributing Member Database Entry
- CDD:cd07479